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目的:探讨异常的脂质代谢、系统炎症指标对肾细胞癌骨转移的影响。方法:回顾性分析2009年11月至2017年11月北京大学人民医院收治的239例肾细胞癌患者的临床资料，其中68例出现骨转移(骨转移组，56例为同时性转移，12例为异时性转移)，171例未发生骨转移(对照组)。骨转移组男53例，女15例；年龄(59.47±11.41)岁；49例(72.1%)有吸烟史，41例(60.3%)既往合并高血压病，56例(82.4%)既往合并糖尿病。对照组男116例，女55例；年龄(58.61±11.10)岁；119例(69.6%)有吸烟史，92例(53.8%)既往合并高血压病，138例(80.7%)既往合并糖尿病。两组患者一般资料比较差异无统计学意义(n P>0.05)。骨转移组平均体质指数[(24.25±4.00)kg/mn 2]低于对照组[(25.41±3.67)kg/mn 2](n P0.05). Somking history (72.1% in RCC-BM group, 69.6% in control group) and concomitant hypertension (60.3% in RCC-BM group, 53.8% in control group), diabetes mellitus (82.4% in RCC-BM group, 80.7% in control group) were comparable between two groups (n P>0.05). Significantly lower body mass index [BMI, (24.25±4.00) kg/mn 2]was found in RCC-BM group comparing to that in control group [(25.41±3.67) kg/mn 2](n P<0.05). RCC stages in RCC-BM group: Tn 1 29 cases, Tn 2 7 cases, Tn 3 18 cases, Tn 4 13 cases; RCC stages in control group: Tn 1 128 cases, Tn 2 8 cases, Tn 3 29 cases, Tn 4 6 cases. Preoperative serum lipid profiles (total triglyceride/TG, total cholesterol/TC, low density lipoprotein cholesterol/LDL-C, high density lipoprotein cholesterol/HDL-C levels) were collected. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were calculated as inflammatory parameters. Binary multivariate logistic regression and univariate analysis (n t test, chi-squared test) were performed.n Results:Significantly increasing LDL-C levels [(2.89±0.76)mmol/L] were found among RCC-BM patients comparing to non-metastatic RCC control patients [(2.61±0.81)mmol/L, n P<0.05]. NLR (3.74±2.23 in RCC-BM group, 2.23±1.68 in control group) and PLR(193.88±139.43 in RCC-BM group, 122.67±54.66 in control group) significantly elevated in RCC-BM group (n P<0.001). Serum LDL-C level was determined to increase hazard ratios of progressing RCC-BM after balancing baseline features, T stages and histological sub-types (n HR=1.766, 95%n CI 1.025-3.043, n P3) had higher risk of developing RCC-BM (n HR=5.052, 95%n CI 1.987-12.845, n P<0.05). Ratio of patients with high LDL-C (≥2.58 mmol/L, 69.2%, 45 cases) was also greater in RCC-BM group (47.4%, 81 cases,n P<0.01).n Conclusions:This study suggests dyslipidemia is associated with RCC-BM. Systematic inflammation is also involved in. LDL-C and NLR could be utilized as predictors to identify high-risk patients to develop RCC-BM.