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ATP敏感性钾通道已被证实广泛分布于血管平滑肌、心肌、胰腺等组织,发挥着诸如血管舒张、心肌缺血的保护及胰岛素分泌等作用。本综述旨在阐明ATP敏感性钾通道在帕金森病发病机制中参与调控神经元电兴奋性、线粒体功能及神经递质释放的独特角色,以揭示对其进行深入研究的意义及作为帕金森病治疗靶点的可能性和潜在价值。
ATP-sensitive potassium channel has been widely distributed in vascular smooth muscle, myocardium, pancreas and other tissues, such as vasodilation, myocardial ischemia protection and insulin secretion and so on. This review aims to elucidate the significance of the ATP-sensitive potassium channel in the pathogenesis of Parkinson’s disease and its role in the regulation of neuronal electrical excitability, mitochondrial function and neurotransmitter release in order to reveal its significance for further study and as a marker of Parkinson’s disease The potential and potential value of therapeutic targets.