论文部分内容阅读
目的 分析妊娠相关血浆蛋白A(PAPP -A)在产前筛查胎儿染色体病时的灵敏度和假阳性。方法 测定13 72例妊娠 7～ 3 2周的孕妇血清PAPP -A水平 ,其中 99例于孕期抽取脐静脉血、羊水或胎儿出生后的外周血确定胎儿染色体核型。结果 99例中染色体核型异常的 2 0例 ,正常的 79例 ;以PAPP -A≤ 0 3 3MoM ,≤ 0 3 5MoM ,≤ 0 43MoM ,≤ 0 60MoM ,≤ 0 85MoM为诊断界点 ,灵敏度分别为 75 % ,80 % ,85 % ,90 % ,95 % ,假阳性率分别 12 % ,13 % ,17% ,2 7% ,43 %。结论 孕期取PAPP -A≤ 0 43MoM为诊断界点可筛查出约 85 %的染色体病胎儿。
Objective To analyze the sensitivity and false positive rate of pregnancy-associated plasma protein A (PAPP-A) in prenatal screening for fetal chromosomal disease. Methods Serum levels of PAPP-A were measured in 13 72 pregnant women between 7 and 322 weeks of gestation. Ninety-nine of the pregnant women received umbilical cord blood, amniotic fluid or fetal peripheral blood after pregnancy to determine the fetal karyotype. Results There were 20 karyotype abnormalities and 79 normal cases in 99 cases. The diagnostic cutoff points were PAPP-A ≤ 0 3 3MoM, ≤ 0 35MoM, ≤ 0 43MoM, ≤ 0 60MoM, ≤ 0 85MoM, respectively The false-positive rates were 75%, 80%, 85%, 90% and 95% respectively. The false-positive rates were 12%, 13%, 17%, 27% and 43% respectively. Conclusion PAPP-A ≤ 0 43MoM is the diagnostic boundary of pregnancy screening for about 85% of chromosome disease fetuses.