有些恶性肿瘤病人对肿瘤抗原有活跃的免疫反应,有些则免疫反应低下,这提示病人细胞免疫受到抑制,但血中淋巴细胞和血清的这些研究结果并不一致,也与病人的生存无关。动物肿瘤模式表明渗入肿瘤的炎症细胞较血中淋巴细胞更能准确地反映肿瘤和宿主的关系。迅速生长的肿瘤内淋巴细胞反应弱或无,在退化的肿瘤内有高度反应的淋巴细胞,这些肿瘤内的免疫反应与区域淋巴结和血中淋巴细胞反应极不相同。人体的研究亦是如此。作者对渗入肿瘤的淋巴细胞(TIL)的免疫抑制及用卡介苗(BCG)做肿瘤 Some patients with malignant tumors have an active immune response to tumor antigens, while others have a low immune response, which suggests that patients’ cellular immunity is inhibited. However, the results of these studies on blood lymphocytes and serum are not consistent and have nothing to do with the patient’s survival. Animal tumor patterns indicate that inflammatory cells infiltrating tumors more accurately reflect tumor-host relationships than blood-borne lymphocytes. The rapidly growing intra-tumor lymphocytes respond weakly or non-efficiently, and there is highly reactive lymphocytes in the degenerated tumors. The immune responses in these tumors are very different from those in regional lymph nodes and blood lymphocytes. The same is true of human studies. The authors of tumor infiltration of lymphocytes (TIL) immunosuppression and the use of BCG (BCG) as a tumor