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结核性胸腔积液中γ干扰素的浓度显著增高,对于鉴别诊断良性和恶性胸腔积液具有重要的临床意义。白细胞介素18(IL-18)是与 IL-1具有相似结构和功能的细胞因子。IL-18主要由活化的巨噬细胞产生,与 IL-12具有协同作用,可以诱导 T 淋巴细胞产生γ干扰素,并驱动辅助诱导 T 淋巴细胞的 Th1细胞分化。本研究旨在探讨测定胸腔积液中 IL-18浓度对于诊断结核性胸腔积液的临床意义。对象与方法 2004年3月至2005年6月连续到广西医科大学呼吸疾病研究所就诊的82例原因不明的胸腔积液患者被收治入院并进入相关的诊断程序。经过仔细询问病史、严格的体格检查、必要的辅助检验以及严密临床治疗观察,最终有67例最终诊断为结核性胸腔积液和癌性胸腔积液的
Tuberculous pleural effusion in the IFN-γ concentration was significantly increased for the differential diagnosis of benign and malignant pleural effusion has important clinical significance. Interleukin 18 (IL-18) is a cytokine with similar structure and function to IL-1. IL-18 is mainly produced by activated macrophages and synergizes with IL-12 to induce T-lymphocytes to produce IFN-γ and to drive the induction of Th1 cell differentiation of T lymphocytes. This study aimed to investigate the clinical significance of determining IL-18 concentration in pleural effusion for the diagnosis of tuberculous pleural effusion. Subjects and Methods From March 2004 to June 2005, 82 consecutive unexplained pleural effusion patients admitted to the Institute of Respiratory Diseases of Guangxi Medical University were admitted to the hospital and entered the relevant diagnostic procedures. After careful examination of medical history, rigorous physical examination, the necessary auxiliary tests and close observation of clinical treatment, the final 67 cases of final diagnosis of tuberculous pleural effusion and cancerous pleural effusion