论文部分内容阅读
目的 :探讨急、慢性乙型肝炎患者血清可溶性白介素 -2受体的变化 ,为诊断病情演变和预后判定寻找可靠的依据。方法 :采用双抗体夹心酶联免疫吸附法测定健康对照 30例和各型乙型肝炎患者 16 7例 ,包括急性乙型肝炎 2 2例 ,慢性乙型肝炎 (轻度 ) 5 4例 ,慢性乙肝 (中～重度 ) 46例 ,肝炎后肝硬化 2 8例 ,慢性重型肝炎 17例 ,并对测定结果进行分析。结果 :各组患者血清SIL -2R均明显高于对照组 (P <0 .0 1) ,其中慢重肝、肝硬化、急性乙肝和慢活肝增高最为显著。Child’sC级乙肝后肝硬化显著高于Child’sB、A级者 (P <0 .0 5 ) ,慢重肝存活病例显著低于死亡病例 (P <0 .0 1)。结论 :急、慢性乙型肝炎患者血清SIL -2R水平均明显升高 ,其水平的高低与机体免疫功能状态及肝细胞损伤程度相关 ,故对乙肝患者病情变化和预后判断有一定意义
Objective: To investigate the changes of serum soluble interleukin-2 receptor in patients with acute and chronic hepatitis B, and to find a reliable basis for the diagnosis of disease progression and prognosis. Methods: Thirty cases of healthy controls and 167 cases of various types of hepatitis B were determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), including 22 cases of acute hepatitis B, 54 cases of chronic hepatitis B (mild), chronic hepatitis B (Moderate to severe) in 46 cases, hepatitis cirrhosis in 28 cases, chronic severe hepatitis in 17 cases, and the results were analyzed. Results: The serum levels of SIL -2R in each group were significantly higher than those in the control group (P <0.01). Among them, the levels of SLH, cirrhosis, acute and chronic liver were the most significant. Child’sC hepatitis B cirrhosis was significantly higher than Child’sB, A class (P <0.05), cases of chronic severe liver disease were significantly lower than the death cases (P <0.01). Conclusion: The levels of serum SIL-2R in patients with acute and chronic hepatitis B are significantly increased, the level of which is related to immune function and the degree of hepatocyte injury, so it has some significance for the change of disease and the prognosis of patients with hepatitis B