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目的探讨原发性肝细胞癌（ｐｒｉｍａｒｙｈｅｐａｔｏｃｅｌｕｌａｒｃａｒｃｉｎｏｍａ，ＰＨＣＣ）肿瘤组织不同部位肿瘤浸润性淋巴细胞（ｔｕｍｏｉｎｆｉｌｔｒａｔｉｎｇｌｙｍｐｈｏｃｙｔｅｓ，ＴＩＬ）的得率和成活率，以便制备ＴＩＬ用于过继免疫治疗时正确切取标本。方法本实验对１２例ＰＨＣＣ肿瘤组织不同部位ＴＩＬ的得率和成活率进行了比较。结果肿瘤周围组织和肿瘤边缘组织ＴＩＬ得率和成活率最高，肿瘤实质组织次之，肿瘤中心坏死组织最低，正常肝脏组织、腹水、胆管癌栓内几乎无ＴＩＬ。结论制备ＰＨＣＣ组织ＴＩＬ时，切取肿瘤周围组织和肿瘤边缘组织效果较好。
Objective To investigate the yield and survival rate of tumor-infiltrating lymphocytes (TILs) in different parts of primary hepatocellular carcinoma (PHCC) so as to prepare TIL for proper removal of specimens during adoptive immunotherapy. Methods In this study, the yield and survival rate of TIL in different parts of 12 PHCC tumor tissues were compared. Results The TIL rate and survival rate of the tumor surrounding tissue and tumor margin tissue were the highest, followed by the parenchymal tumor tissue, the lowest necrosis tissue in the tumor center, and almost no TIL in the normal liver tissue, ascites and cholangiocarcinoma. Conclusion When TIL is prepared, it is better to cut the tissue around the tumor and the edge of the tumor.