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基因调控是分子生物学中的核心问题,它涉及到细胞生长、分化、衰老及个体的发育,肿瘤、心血管、代谢等方面疾病发生的分子基础。转录水平上的调控是基因调控的关键,它主要包括两个内容,即顺式调控元件和反式作用因子。基因表达的严格组织和细胞特异性与反式作用因子密切相关,因此这是当前研究的热点之一。介素6-核因子(NF-IL6)作为反式作用因子是在90年代初克隆成功的,它不仅能与各种急期蛋白以及与炎症有关的细胞因子的基因调控区结合,在转录水平上对这些基因的表达起正调控作用,而且还能与某些病毒基因的增强子结合,表现出负调控作用。本文综述了NF-IL6的结构、功能及其在基因调节中可能发挥的作用。
Gene regulation is the core issue in molecular biology. It involves the molecular basis of diseases such as cell growth, differentiation, senescence and individual development, tumor, cardiovascular and metabolism. Regulation at the transcriptional level is the key to gene regulation, which mainly includes two components: cis-regulatory elements and trans-acting factors. Strict organization of the gene expression and cell specificity and trans-acting factors are closely related, so this is one of the hot spots of current research. Nuclear factor (NF-IL6) as a trans-acting factor was cloned in the early 90s successful, it not only with a variety of acute proteins and inflammation associated cytokines gene regulatory region binding, at the transcriptional level On the expression of these genes play a positive regulatory role, but also with some enhancers of the viral gene binding, showing a negative regulatory role. This review summarizes the structure, function and possible role of NF-IL6 in gene regulation.