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目的:探讨细针穿刺抽吸细胞学活检在甲状腺结节诊断中的应用价值。方法:选择甲状腺结节患者200例,均接受超声和甲状腺功能检查,采用细针穿刺抽吸细胞学活检(FNAC)和丝/苏氨酸特异性激酶基因V600E(BRAF V600E)突变分析,研究其应用价值。结果:FNAC检测与病理符合率为76.5%,BRAFV600E检测与病理符合率为87.0%,二者联合检测的敏感度为92.3%,特异性为97.6%。结论:FNAC与BRAF联合应用,其特异性、敏感性更高,建议联合应用。
Objective: To investigate the value of fine needle aspiration biopsy in the diagnosis of thyroid nodules. Methods: 200 patients with thyroid nodules were selected and underwent ultrasound and thyroid function tests. The mutation of FNAC and BR600 V600E was studied by using the needle aspiration cytology biopsy (FNAC) Value. Results The coincidence rate between FNAC and pathology was 76.5%. The coincidence rate between BRAFV600E and pathology was 87.0%. The sensitivity and specificity of the combined detection of the two methods were 92.3% and 97.6% respectively. Conclusion: The combination of FNAC and BRAF has higher specificity and sensitivity. It is suggested that FNAC should be used in combination.