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醋氨酚(即对乙酰基酚,paracetamol)中毒患者初诊时一般情况尚好,但以后可死于暴发性肝功能损害。目前还缺乏预测其后果的满意方法。血浆醋氨酚浓度仅能大致反映肝损害的程度,其血浆半衰期亦受本药连续吸收以及起病时肝功能损害的影响。醋氨酚对肝脏的毒性作用是由其中间代谢产物所引起,因此,血浆中未经代谢的醋氨酚浓度不能可靠地判断预后。~(140碳-氨基比林呼气试验能测定肝细胞微粒体酶类的活力,后者正是醋氨酚过量后受损害最重之处。作者等认为本试验可能早期反映肝损害的程度。共检查30例,其中男11例,女19例;年龄16～18岁。均至少服过10g醋氨酚。服药后4小时的血浆醋氨酚浓度都超过120mg/l。大多数患者经过洗胃、巯基乙胺(Mercaptamine)及其他保肝治疗。~(14)碳-氨基比
Acetaminophen (paracetamol) paracetamol poisoning in patients with newly diagnosed cases is generally good, but later may die of fulminant hepatic dysfunction. There is still no satisfactory way to predict the consequences. Plasma acetaminophen concentration can only roughly reflect the extent of liver damage, the plasma half-life also by the continuous absorption of this drug and the onset of liver function damage. The toxic effect of acetaminophen on the liver is caused by its intermediate metabolites, so that the unmetabolized concentration of acetaminophen in the plasma can not reliably predict the prognosis. ~ (140 carbon-aminopyrine breath test can measure the activity of liver cell microsomes enzyme, which is the most affected place after acetaminophen overdose. The authors believe that this test may reflect the degree of early liver damage .A total of 30 cases were examined, including 11 males and 19 females, aged from 16 to 18 years.All at least 10 g of acetaminophen were taken.At 4 hours after taking the drug, the plasma concentrations of acetaminophen exceeded 120 mg / Gastric lavage, Mercaptamine, and other hepatoprotective therapies ~ (14) Carbon-amino ratio