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目的探讨Ciz1-V蛋白在卵巢浆液性腺癌中的表达及临床意义。方法收集40例卵巢浆液性腺癌标本及27例非卵巢浆液性腺癌标本,采用免疫组化法检测Ciz1-V蛋白表达,分析其表达情况及与临床病理特征的关系。结果 Ciz1-V蛋白在卵巢浆液性腺癌标本中阳性表达例数少于非卵巢浆液性腺癌标本(P<0.01)。在卵巢浆液性腺癌标本中,Ciz1-V蛋白阳性表达与肿瘤分级和国际妇产科联盟(FIGO)分期有关(P<0.05)。结论 Ciz1-V蛋白在卵巢浆液性腺癌中呈现低表达,其表达情况与肿瘤分级和FIGO分期相关。
Objective To investigate the expression of Ciz1-V protein in ovarian serous adenocarcinoma and its clinical significance. Methods 40 specimens of ovarian serous adenocarcinoma and 27 specimens of non-ovarian serous adenocarcinoma were collected. The expression of Ciz1-V protein was detected by immunohistochemistry. The relationship between the expression of Ciz1-V and clinicopathological features was analyzed. Results The positive number of Ciz1-V protein in ovarian serous adenocarcinoma specimens was lower than that in non-ovarian serous adenocarcinoma specimens (P <0.01). In ovarian serous adenocarcinoma specimens, Ciz1-V protein expression was correlated with tumor grade and FIGO staging (P <0.05). Conclusions The expression of Ciz1-V protein is low in ovarian serous adenocarcinoma. The expression of Ciz1-V is correlated with tumor grade and FIGO staging.