论文部分内容阅读
目的观察钙拮抗剂盐酸维拉帕米和阿苯达唑单独及联合用药治疗小鼠继发性包虫病的疗效,探讨钙离子拮抗剂对棘球蚴的作用机理。方法小鼠随机分成维拉帕米和阿苯达唑单用药组、维拉帕米+阿苯达唑用药组、对照组。给药治疗90 d后,解剖小鼠,取棘球蚴组织,进行病理组织学和超微结构观察。结果盐酸维拉帕米和阿苯达唑单独及联合应用90 d后,棘球蚴生长受到抑制,抑制率分别为47.2%、43.4%和56.6%,联合用药组与单独用药组比较差异有统计学意义(P<0.05)。电镜观察盐酸维拉帕米对小鼠棘球蚴组织损伤严重。结论盐酸维拉帕米联合阿苯达唑治疗小鼠继发性棘球蚴其效果比使用二者单独治疗小鼠继发性棘球蚴病效果好。
Objective To observe the efficacy of calcium antagonist verapamil and albendazole in the treatment of secondary echinococcosis in mice and explore the mechanism of calcium antagonist on hydatid cyst. Methods The mice were randomly divided into verapamil and albendazole monotherapy group, verapamil + albendazole treatment group and control group. After treatment for 90 days, the mice were dissected and echinococcus granulosus was taken for histopathological and ultrastructural observation. Results After 90 days of verapamil hydrochloride and albendazole alone or in combination, the growth of hydatid cysts was inhibited with the inhibition rates of 47.2%, 43.4% and 56.6%, respectively. The differences between the combination group and the drug alone group were statistically significant Significance (P <0.05). Electron microscopy of verapamil hydrochloride on mouse echinococcosis tissue damage. Conclusion The effect of verapamil hydrochloride combined with albendazole in the treatment of secondary echinococcus granulosus in mice is better than that of the secondary echinococcosis treated mice alone.