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目的:研究加味愈白丸对实验性白癜风模型豚鼠的治疗作用,为临床用药提供依据。方法:采用氢醌脱色法制备实验性白癜风豚鼠模型,观察加味愈白丸低、中、高剂量组及阳性对照组对实验性白癜风模型豚鼠血液中酪氨酸酶、单胺氧化酶(MAO)、胆碱酯酶(CHE)和丙二醛(MDA)、免疫器官脏器系数、血液流变学各项指标以及皮肤黑色素的影响。结果:加味愈白丸能够使模型豚鼠血浆中酪氨酸酶含量明显增多,MAO值降低,CHE活力降低,MDA含量减少,免疫功能增强,血液粘稠度降低以及皮肤黑色素的生成增加。结论:加味愈白丸对实验性白癜风模型豚鼠有一定的治疗作用。
Objective: To study the therapeutic effect of Jiaweiyuai Wan Wan on experimental vitiligo model guinea pigs and provide the basis for clinical use. Methods: The model of experimental vitiligo guinea pig was prepared by decoloration of hydroquinone. The effects of low, medium and high dose Jiaweibaixu and positive control group on tyrosinase, monoamine oxidase (MAO), cholinesterase Enzyme (CHE) and malondialdehyde (MDA), organ coefficient of immune organs, indexes of hemorheology and melanin of skin. Results: Jiaweiyuaiwan Pill could significantly increase the content of tyrosinase in the plasma, the decrease of MAO, the decrease of CHE activity, the decrease of MDA content, the increase of immune function, the decrease of blood viscosity and the increase of skin melanin production. Conclusion: Jiaweiyuai Wan Wan experimental guinea pig model of vitiligo have a certain therapeutic effect.