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目的:调查舒芬太尼注射剂不良反应的临床表现和诱发因素,为药物的安全应用提供参考。方法:采用病历回顾性研究方法,对我院173份使用舒芬太尼注射剂的完整住院病历进行调查,用SPSS12.0进行统计分析。结果:173例使用舒芬太尼注射剂的不良事件33例(19.08%),其中不良反应17例(9.83%)。不良反应的临床类型无显著性差异(P>0.05),心血管与胃肠道反应较为常见,不良反应与年龄、性别、合并用药无关(P分别为>0.05),与给药剂量和方法有关(P<0.01),不良反应多出现在用药2～6h(P<0.05)。结论:掌握舒芬太尼注射剂发生不良反应的临床表现和诱发因素,使其应用更为安全。
Objective: To investigate the clinical manifestations and predisposing factors of sufentanil injection adverse reactions and provide reference for the safe application of drugs. Methods: A retrospective study of medical records of our hospital 173 sufentanil injection of the complete hospital medical records were investigated using SPSS12.0 statistical analysis. Results: A total of 173 adverse events (19.08%) were observed in 173 patients with sufentanil injection, of which 17 were adverse reactions (9.83%). There was no significant difference in the clinical types of adverse reactions (P> 0.05). Cardiovascular and gastrointestinal reactions were more common. Adverse reactions were not related to age, sex, and combined medication (P> 0.05, respectively) (P <0.01), adverse reactions occurred in the treatment of 2 ~ 6h (P <0.05). Conclusion: To master the clinical manifestations and predisposing factors of adverse reactions of sufentanil injection makes it safer to use.