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目的:系统评价炎琥宁注射液治疗手足口病的临床疗效与安全性。方法:检索Cochrane Library,EBSCO,EMbase,Pub Med,CBM,VIP,CNKI和Wanfang Data数据库,查找有关炎琥宁治疗手足口病的随机对照试验(RCT),检索时限均从建库至2014年10月;按纳入与排除标准独立筛选文献、提取资料和评价质量后,采用Rev Man 5.3软件进行Meta分析。结果:共纳入51个RCT,病例共7 718例。Meta分析结果显示:炎琥宁注射液组或炎琥宁联合利巴韦林组在总有效率、患者退热时间、疱疹消退时间以及溃疡消退时间比单用利巴韦林更具有优势,其差异具有统计学意义。在安全性方面,使用炎琥宁注射液不良反应发生率为2.48%,略低于利巴韦林对照组2.57%。结论:炎琥宁注射液治疗手足口病有较好的疗效并且不良反应发生率较低。但因纳入文献总体质量较差,尚需设计更加严谨的多中心、大样本的随机对照试验进一步证实结论。
Objective: To systematically evaluate the clinical efficacy and safety of YanHuNing injection in the treatment of HFMD. Methods: Randomized controlled trials (RCTs) were conducted to search the Cochrane Library, EBSCO, PubMed, PubMed, CBM, VIP, CNKI and Wanfang Data databases for the search of Yanhu Ning’s treatment of HFMD. Month; According to inclusion and exclusion criteria independent screening of documents, data extraction and quality evaluation, the use of Rev Man 5.3 software for meta-analysis. Results: A total of 51 RCTs were included, with a total of 7 718 cases. The result of Meta analysis showed that the total effective rate, the patient’s antipyretic time, the herpes remission time and the ulcer subsidence time were more superior than the ribavirin alone in the Yanhuaning injection group or the Yanhuanen plus ribavirin group The difference was statistically significant. In terms of safety, the incidence of adverse reactions using Yanhuoning Injection was 2.48%, slightly lower than that of ribavirin control group 2.57%. Conclusion: Yanhuning injection has good curative effect on hand-foot-mouth disease and low incidence of adverse reactions. However, due to the poor quality of the included literature, a more rigorous multicenter design is still needed. Large randomized controlled trials further confirm the conclusion.