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目的总结分析糖皮质激素局部鼓室内注射法治疗难治性突聋的临床效果,为突聋患者提供另一种治疗方法。方法对23例经常规扩血管、营养神经及溶栓治疗无效的突发性耳聋患者,采用鼓膜穿刺鼓室内注入甲基强的松龙1 mL治疗,每周2次,2周为1个疗程。比较患者治疗前后言语频率气导的纯音听阈平均值(PTA)。结果 10例治疗后PTA值减少10 dB HL以上。治疗前后的PTA分别为(83.47±13.69)dB HL和(75.13±15.79)dB HL,治疗前后PTA的差异有统计学意义(t=5.12,P<0.01),患者均未出现并发症。结论糖皮质激素鼓室内注射对部分难治性突发性耳聋患者仍有一定疗效,可作为常规药物治疗无效患者的另一种治疗选择。
Objective To summarize and analyze the clinical effect of glucocorticoid local intratympanic injection in the treatment of refractory sudden deafness and provide another treatment for sudden deafness. Methods Twenty-three patients with sudden deafness who were treated by conventional vasodilators, nutritional nerves and thrombolytic therapy were treated with 1 mL methylprednisolone by tympanic membrane, twice a week and 2 weeks as a course of treatment . The mean pure tone hearing threshold (PTA) was compared between patients with speech frequency before and after treatment. Results After treatment, PTA decreased by 10 dB HL in 10 cases. The PTA before and after treatment were (83.47 ± 13.69) dB HL and (75.13 ± 15.79) dB HL, respectively. There was no significant difference in PTA between before and after treatment (t = 5.12, P <0.01). Conclusions Glucocorticoid intratympanic injection has some curative effect on some patients with refractory sudden deafness and may be used as another treatment option for patients with ineffective conventional drug therapy.