结缔组织生长因子(connective tissue growth factor,CTGF)是即刻早期基因CCN家族成员之一,其生物学效应包括刺激细胞增生、迁移,细胞外基质的生成,新生血管形成,细胞黏附,细胞凋亡等。因此,它广泛参与了机体胚胎发育、骨形成、组织纤维化、疤痕增生、创伤修复和新生血管形成等 Connective tissue growth factor (CTGF) is a member of the immediate early gene CCN family and its biological effects include stimulating cell proliferation, migration, extracellular matrix formation, neovascularization, cell adhesion, apoptosis and the like . Therefore, it is widely involved in embryo development, bone formation, tissue fibrosis, scar hyperplasia, wound repair and neovascularization