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目的 通过回顾性总结 ,提高对慢性肺间质病的认识。方法 回顾性分析 4 8例慢性肺间质纤维化患者的临床特点和肺功能情况。结果 4 8例患者分为二组。特发性肺间质纤维化 (IPF)组 2 6例 (5 4 % ) ,继发性肺间质纤维化组 2 2例 (46 % )。IPF组年龄偏大 ;多数有爆裂音 ,占 39.6 % (19/ 4 8) ,杵状指者占 10 .4 % (5 / 4 8) ;CT/HRCT表现比较典型。两组肺功能改变主要为限制性的通气障碍和弥散功能降低。IPF组肺活量 (VC)和肺总量(TLC)较继发性组下降明显 ,P <0 .0 5。一秒率 (FEV1% )在正常范围 ,一氧化碳弥散量 (DLCO)下降显著且早 ,是较敏感的基础肺功能指标。结论 特发性肺间质纤维化和继发性肺间质纤维化的临床特征和肺功能各异
Objective To retrospectively summarize and raise awareness of chronic interstitial lung disease. Methods The clinical features and pulmonary function of 48 patients with chronic pulmonary fibrosis were retrospectively analyzed. Results 48 patients were divided into two groups. 26 cases (54%) in idiopathic pulmonary interstitial fibrosis (IPF) group and 22 cases (46%) in secondary interstitial fibrosis group. The IPF group was older; most had crackles, accounting for 39.6% (19/48), clubbing accounted for 10.4% (5/48); CT / HRCT performance was typical. Pulmonary function changes in both groups were mainly restricted ventilation and decreased diffusibility. IPF group lung capacity (VC) and total lung volume (TLC) decreased significantly than the secondary group, P <0. The one-second rate (FEV1%) is within the normal range and the DLCO decreases significantly and early and is a more sensitive baseline lung function indicator. Conclusions Idiopathic pulmonary fibrosis and secondary pulmonary fibrosis clinical features and different lung function