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目的对生脉辅半饱合量西地兰治疗婴幼儿肺炎合并心力衰竭进行临床观察研究。方法选择2002年10月至2006年2月90例肺炎心衰住院患儿,随机分为治疗组(生脉辅半饱合量西地兰)、全量组(饱合量西地兰)、半量组(半饱合量西地兰),分别以3种方法行心衰治疗。结果治疗组显效19例(63.3%)、有效11例(36.7%);全量组显效22例(73.3%)、有效8例(26.7%);半量组显效5例(16.7%)、有效15例(50%)、无效10例(33.3%)。经统计学处理,治疗组与全量组疗效差异无统计学意义,(P>0.05);而半量组较以上两组差异有统计学意义(P<0.01)。治疗组和全量组在呼吸困难、心率增快、心音低钝、肝脏肿大的体征改善及完全恢复方面差异无统计学意义(均P>0.05)。结论生脉辅半饱合量西地兰治疗婴幼儿肺炎合并心衰较西地兰饱合疗法疗效相当,是安全有效的,减少了西地兰的用量,避免了西地兰中毒的发生。
Objective To study the clinical effect of Shengmai supplementation with half-saturation of cedilanid in the treatment of infantile pneumonia complicated with heart failure. Methods From October 2002 to February 2006, 90 infants with pneumonia and heart failure were randomly divided into two groups: treatment group (Shengmai, half-saturation cedilanid), full-dose group (saturated cedilanidium) Group (half-saturation of cedilanid), respectively, three kinds of methods of heart failure treatment. Results In the treatment group, there were 19 cases (63.3%) effective and 11 cases (36.7%) effective. In the whole group, 22 cases (73.3%) were effective and 8 cases (26.7% (50%), invalid in 10 cases (33.3%). There was no significant difference in therapeutic effect between the treatment group and the full-dose group (P> 0.05). The difference between the two groups was statistically significant (P <0.01). There was no significant difference between the treatment group and the whole group in dyspnea, fasting heart rate, low heart sound, signs of liver enlargement and complete recovery (all P> 0.05). Conclusion Shengmai supplement half-saturation of cedilanid treatment of infantile pneumonia with heart failure compared with cedilanid treatment is quite effective, is safe and effective, reducing the amount of cedilanid and avoiding the occurrence of cedilanid.