目的提高对重症急性胰腺炎 (SAP)合并真菌感染的认识。方法 4 3例患者的腹腔渗液中培养真菌阳性 ,均给予氟康唑 0 .2 g ,2次 /d静脉滴注 ,5天为 1个疗程。观察其疗效并结合文献分析SAP合并真菌感染的发病趋势、危险因素、治疗与预后。结果腹腔渗液真菌培养菌谱中几乎均为念珠菌。 4 3例中 11例死亡 ,32例治愈。结论SAP合并真菌感染发生率近年明显上升 ,是SAP后期的主要致死原因。 Objective To improve understanding of severe acute pancreatitis (SAP) complicated with fungal infection. Method 4 3 cases of patients with peritoneal effusion fungal positive, were given fluconazole 0.2 g, 2 times / d intravenous infusion, 5 days for a course of treatment. To observe the curative effect and analyze the incidence trend, risk factors, treatment and prognosis of SAP with fungal infection combined with the literature. Results peritoneal effusion fungal culture almost all Candida bacteria spectrum. Eleven of 43 patients died and 32 were cured. Conclusions The incidence of SAP complicated with fungal infection increased significantly in recent years, which is the main cause of death in the later stage of SAP.