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Notch通路在肿瘤发生发展、迁移、转移及血管形成方面起着重要作用,也能维持肿瘤干细胞状态,决定其肿瘤形成及分化。笔者就Notch信号通路在胆管癌中的最新研究进行综述。
Notch pathway plays an important role in the development, migration, metastasis and angiogenesis of tumor, and can maintain the status of tumor stem cells and determine its tumor formation and differentiation. The author reviews the latest research of Notch signaling pathway in cholangiocarcinoma.