外贝加尔北部地球化学环境的特点影响着人体内的生物化学过程。研究工作者和临床医生都面临一个问题,即在新来建设贝加尔阿穆尔铁路干线的人群中是否可能发生地方性甲状腺肿和大骨节病。关于大骨节病生化变化的报道为数不多,且常常互相矛盾。因此,我们试图查明该病受累组织中进行的酶反应的特点,试图区分出对该病有相对特异性的一些变化。 The characteristics of the geochemical environment in the northern part of the outer Baikal affect the biochemical processes in the human body. Both researchers and clinicians face the question of whether endemic goitre and Kashin-Beck disease may occur in new arrivals to the Amur Railway in Baikal. There are only a few reports on the biochemical changes of KBD and often contradict each other. Therefore, we sought to ascertain the nature of the enzyme reaction in the affected tissues of the disease in an effort to distinguish between some changes that are relatively specific to the disease.