目的比较尼可地尔与单硝酸异山梨酯治疗稳定型心绞痛的疗效。方法 80例冠心病稳定型心绞痛患者,随机分为研究组和对照组各40例。两组在基础治疗前提下,研究组加用尼可地尔片,对照组加用单硝酸异山梨酯片治疗,治疗期4周。观察所有患者心绞痛缓解情况、主要心血管不良事件及不良反应。结果 80例患者均完成4周治疗,无1例退出。治疗期内均未发生死亡、心肌梗死、脑卒中事件,研究组心绞痛缓解情况明显优于对照组,差异有统计学意义(P<0.05)。研究组未出现明显低血压情况,出现轻微头痛5例,对照组出现低血压2例、轻微头痛12例、中度头痛4例,两组比较差异有统计学意义(P<0.05)。结论尼可地尔对稳定型心绞痛具有很好的缓解作用。 Objective To compare the efficacy of nicorandil and isosorbide mononitrate in the treatment of stable angina pectoris. Methods Eighty patients with coronary heart disease with stable angina were randomly divided into study group (40 cases) and control group (40 cases). The two groups under the premise of basic treatment, the study group plus nicorandil tablets, the control group plus isosorbide mononitrate tablets treatment, the treatment period of 4 weeks. All patients were observed angina relief, major adverse cardiovascular events and adverse reactions. Results 80 patients completed 4 weeks of treatment, no patient withdrew. No death, myocardial infarction and stroke were found in the treatment group. The relief of angina pectoris in the study group was significantly better than that in the control group (P <0.05). In the study group, there were no obvious hypotension, 5 cases of mild headache, 2 cases of hypotension in the control group, 12 mild headache and 4 moderate headache. There was significant difference between the two groups (P <0.05). Conclusion Nicorandil has a good relief effect on stable angina pectoris.