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近十年来对锌在镰状红细胞病中的作用认识上有了很大进展。患此病的病人经常表现为生长停滞、性功能低下、性成熟迟缓以及其他典型的缺锌症状。患者血浆、发及中性粒细胞中锌水平明显降低,碳酸酐酶活性降低,中性粒细胞碱性磷酸酶活性降低。口服生理剂量的锌(醋酸锌)能叫正多数患者的雄激素缺乏,次正常的生长和性发育。药理剂量的锌则能缓解某些症状如疼痛的频繁发作、疼痛的剧烈程度,也能弥补某些生化缺陷,包括减少不可逆的已镰状化的红细胞数,增加红细胞的氧亲合力,改善镰状红细胞
In the past decade, great progress has been made in understanding the role of zinc in sickle cell disease. Patients with this condition often exhibit stagnant growth, sexual dysfunction, delayed sexual maturity, and other typical symptoms of zinc deficiency. Patients with plasma, hair and neutrophil zinc levels were significantly lower carbonic anhydrase activity decreased neutrophil alkaline phosphatase activity decreased. Oral physiological doses of zinc (zinc acetate) can be called the majority of patients with androgen deficiency, subnormal growth and sexual development. Pharmacological doses of zinc can alleviate some of the symptoms such as frequent episodes of pain, the severity of pain, and also make up for some biochemical deficiencies, including reducing the irreversible number of sickle red blood cells, increasing the oxygen affinity of red blood cells, and improving sickness Red blood cells