抗病毒治疗为乙型肝炎治疗的难题。目前世界公认的有效且被证实的药物α干扰素，对于乙型肝炎病毒复制指标的阴转率为２０％～６０％［１，２］，疗效不满意，因而国内外学者近年来都将目光投注于基因治疗。基因治疗是将治疗性基因导入到发生病变的细胞内，以替代突变基因的 Antiviral therapy for the treatment of hepatitis B problem. The currently recognized and validated interferon alpha in the world has a negative conversion rate of 20% -60% for indicators of hepatitis B virus replication [1,2], and its efficacy is not satisfactory. Therefore, both domestic and foreign scholars in recent years have Focus on gene therapy. Gene therapy is the introduction of therapeutic genes into diseased cells to replace the mutated genes