论文部分内容阅读
动态观察了乙醇摄入对小鼠肝功能及磺胺嘧啶（ＳＤ）代谢动力学的影响。结果表明，每天以２５ｇ／ｋｇ乙醇摄入２周，ＳＧＳＴ活性明显升高，随着摄入时间的延长，在一定时间范围内呈进行性增高，同时，ＳＡＬＴ活性也与乙醇摄入时间呈明显正相关，提示长期乙醇摄入对肝脏的不利影响。乙醇对肝匀浆中ＧＳＴ和苯胺羟化酶活性呈双重作用，早期具有诱导酶活性的作用，但诱导的时间和强度不同，后期则可抑制酶的活性。ＳＤ在小鼠体内的代谢符合二房室模型，乙醇对ＳＤ的代谢具有双相作用，早期使ＳＤ代谢加速，后期则使代谢延缓，表明乙醇对代谢ＳＤ的Ｎ乙酰化酶可能具有酶促酶抑双重作用。
The effects of ethanol intake on the liver function and the metabolism of sulfadiazine (SD) were observed dynamically. The results showed that daily intake of 2 5g / kg ethanol for 2 weeks, SGST activity was significantly increased, with the intake of time, increased within a certain period of time increased at the same time, SALT activity and ethanol intake time Showed a significant positive correlation, suggesting long-term adverse effects of ethanol intake on the liver. Ethanol had a dual effect on GST and aniline hydroxylase activity in liver homogenate, which had the effect of inducing enzyme activity in early stage. However, the induction time and intensity were different, and the enzyme activity was inhibited in later stage. Metabolism of SD in mice accorded with two-compartment model. Ethanol had a biphasic effect on the metabolism of SD, accelerating SD metabolism in the early stage and postponing the metabolism, suggesting that ethanol might have enzymatic enzymes for N-acetylating enzymes that metabolize SD Inhibit dual role.