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多发性硬化是一种病因不明的中枢神经系统慢性脱髓鞘性炎症性疾病。趋化因子是一类具有趋化功能的细胞因子,在向炎症区募集并激活白细胞中发挥着主要作用,其与多发性性硬化的发生、发展与转归关系密切,将为揭示多发性硬化的发病机制、寻找诊断和治疗多发性硬化的新靶点提供新的契机。本文将对趋化因子及受体的分类、特性、致炎机制,及其与多发性硬化(MS)的关系进行阐述。
Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous system of unknown etiology. Chemokines, a class of chemotactic cytokines, play a major role in the recruitment and activation of leukocytes in inflammatory areas and are closely related to the development, progression and prognosis of multiple sclerosis and will be useful in revealing multiple sclerosis The pathogenesis, looking for new targets for the diagnosis and treatment of multiple sclerosis provides a new opportunity. This article describes the classification of chemokines and receptors, their characteristics, the mechanism of inflammation, and their relationship with multiple sclerosis (MS).