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One key of constructing ideal transdermal drug delivery system(TDDS)is enhancing the percutaneous rate of drugs without sacrificing compatibility.Ethosomes(Eths)have excellent transdermal performance as well as good biocompatibility,and thus been widely used as drug carrier.Hydrogel has good 3-dimensional mesh structure which is convenience for drugs release and storage.In this study,Eths were introduced into silk fibroin(SF)/polyvinyl alcohol(PVA)composite hydrogel to construct a novel TDDS through a green process.The Ethsomes(Eths)-SF/PVA composite hydrogel TDDS showed good mechanical properties(stress:(0.236±0.032)MPa;strain:(65.74±2.45)%).Also,skin fibroblasts can grow and proliferate well on this TDDS,indicating that this material has a good cytocompatibility.Furthermore,with doxorubicin hydrochloride(Dox)as a model drug loaded in ethosomes,in vitro studies showed that this TDDS was able to transdermally release Dox efficiently.Our data suggested this novel system had a good potential for application in TDD,though further evaluative study still needed to carry out.
One key of constructing ideal transdermal drug delivery system (TDDS) is enhancing the percutaneous rate of drugs without sacrificing compatibility. Ethosomes (Eths) have excellent transdermal performance as well as good biocompatibility, and has been widely used as a drug carrier. Hydrogel has good 3 -dimensional mesh structure which is convenience for drugs release and storage. In this study, Eths were introduced into silk fibroin (SF) / polyvinyl alcohol (PVA) composite hydrogel to construct a novel TDDS through a green process. Ethsomes SF / PVA composite hydrogel TDDS showed good mechanical properties (stress: (0.236 ± 0.032) MPa; strain: (65.74 ± 2.45)%). Also, skin fibroblasts can grow and proliferate well on this TDDS, indicating that this material has a good cytocompatibility. Future plus, with doxorubicin hydrochloride (Dox) as a model drug loaded in ethosomes, in vitro studies showed that this TDDS was able to transdermally release Dox efficiently. Our data suggested this novel system had a good pot ential for application in TDD, though further evaluative study still needed to carry out.