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1965年祝寿河教授首次应用山莨菪碱(654-2)治疗感染性休克以来,654-2的基础研究和临床应用颇引人注目,近来,苏静怡教授等发现,654-2还能保护休克大鼠胰腺细胞的溶酶体膜,为从细胞水平上研究与应用654-2提供了新信息.我们设想这种药物对缺氧的心肌细胞也可能具有保护作用.据此,观察了654-2对缺氧离体大鼠心肌超微结构的影响.
Since the first application of anisodamine (654-2) to treat septic shock in 1965 by Professor Zhu Shouhe, the basic research and clinical application of 654-2 has drawn considerable attention. Recently, Professor Su Jingyi found that 654-2 can also protect large shock The lysosomal membrane of mouse pancreatic cells provides new information for the study and application of 654-2 at the cellular level.We hypothesize that this drug may also have a protective effect on hypoxic cardiomyocytes.Accordingly, Effect of hypoxia isolated myocardium ultrastructure in rats.