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目的探讨孟鲁司特钠联合双水平气道正压通气(BiPAP)治疗慢性阻塞性肺疾病合并阻塞性睡眠呼吸障碍重叠综合征(OS)的临床疗效。方法 103例重叠综合征患者随机分为试验组51例和对照组52例,试验组给予孟鲁司特钠联合BiPAP呼吸机治疗对照组单用BiPAP治疗2组疗程均为4周。比较2组治疗前后的血清C-反应蛋白水平、血气分析相关指标和肺功能指标。结果治疗前后,2组C-反应蛋白水平显著降低(P<0.05),且试验组显著低于对照组(P<0.05)。2组治疗前后睡眠呼吸暂停低通气指数、二氧化碳分压显著下降(P<0.05)血氧分压、一秒用力呼气容积占预计值百分比、一秒用力呼气容积/用力肺活量显著上升(P<0.05)。结论孟鲁司特钠联合BiPAP呼吸机治疗重叠综合征有较好的临床疗效。
Objective To investigate the clinical efficacy of montelukast sodium combined with bilevel positive airway pressure (BiPAP) in the treatment of patients with obstructive sleep apnea syndrome (OS) complicated by chronic obstructive pulmonary disease. Methods A total of 103 patients with overlapping syndrome were randomly divided into experimental group (n = 51) and control group (n = 52). Patients in the experimental group received montelukast sodium combined with BiPAP ventilator. The control group received BiPAP alone for 4 weeks. The levels of serum C-reactive protein, blood gas analysis and lung function were compared between the two groups before and after treatment. Results Before and after treatment, the levels of C-reactive protein in two groups were significantly decreased (P <0.05), and the experimental group was significantly lower than the control group (P <0.05). Sleep apnea-hypopnea index and carbon dioxide partial pressure decreased significantly (P <0.05) in two groups before and after treatment, and the forced expiratory volume in one second accounted for a percentage of predicted value, and forced expiratory volume / forced vital capacity in one second increased significantly <0.05). Conclusion Montelukast combined with BiPAP ventilator in the treatment of overlapping syndrome has a good clinical efficacy.