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幽门螺杆菌(HP)是慢性胃炎及消化性溃疡的重要病因之一,与胃癌密切相关,世界卫生组织国际癌症研究机构(IARC)已将其列为Ⅰ级致癌因子。然而,幽门螺杆菌可导致胃黏膜组织炎症,其持续性炎症诱发恶性转化的机制也有待进一步研究。该文介绍了幽门螺杆菌的传播、致病机理等基本信息,并着重介绍了根除治疗的联合用药疗法。常用的根治方案药物分为单一用药和联合用药,主要是三联疗法和四联疗法。二联疗法是同时使用质子泵抑制剂加羟氨苄青霉素;三联疗法是以铋剂为主,再用2种抗生素或以1种质子泵抑制剂为主加用2种抗生素;四联疗法为质子泵抑制剂加铋剂加2种抗生素。该文汇总了近些年常用的治疗方法,并分析其利弊。
Helicobacter pylori (HP) is one of the important causes of chronic gastritis and peptic ulcer, and is closely related to gastric cancer. The World Health Organization’s International Agency for Research on Cancer (IARC) has listed it as Class I oncogenic factor. However, Helicobacter pylori can cause inflammation of gastric mucosal tissue, and the mechanism of persistent inflammation-induced malignant transformation remains to be further studied. This article describes the transmission of Helicobacter pylori, pathogenesis and other basic information, and focuses on the eradication therapy combination therapy. Commonly used radical program drugs are divided into a single medication and combination therapy, mainly triple therapy and quadruple therapy. Dual therapy is the simultaneous use of proton pump inhibitors plus amoxicillin; triple therapy is based on bismuth, then two antibiotics or a proton pump inhibitor plus two antibiotics; quadruple therapy for the proton Pump inhibitor plus bismuth plus two antibiotics. This article summarizes the treatment methods commonly used in recent years and analyzes the advantages and disadvantages.