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目的探讨氯沙坦治疗社区原发性高血压病对血压控制及蛋白尿改善的效果。方法选择2014年9月—2015年9月宁波市鄞州区古林镇卫生院收治的80例原发性高血压病患者,按照随机数表法分为对照组(40例)和观察组(40例),对照组给予氢氯噻嗪治疗,观察组给予氯沙坦治疗,比较两组患者治疗前后血压〔收缩压(SBP)、舒张压(DBP)〕及蛋白尿〔尿微量清蛋白(m AIb)、尿β2微球蛋白(β2-MG)〕及不良反应情况。结果治疗前两组患者SBP、DBP比较,差异无统计学意义(P>0.05),治疗后观察组SBP、DBP低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者m AIb、β2-MG水平比较,差异无统计学意义(P>0.05),治疗后观察组m AIb、β2-MG水平低于对照组,差异有统计学意义(P<0.05)。两组患者均未发生不良反应。结论氯沙坦治疗社区原发性高血压病可对患者血压进行有效控制并改善蛋白尿水平。
Objective To investigate the effect of losartan on blood pressure control and proteinuria in community-based patients with essential hypertension. Methods From September 2014 to September 2015, 80 patients with essential hypertension admitted to GuLin Hospital, Yinzhou District, Ningbo City were divided into control group (40 cases) and observation group (40 cases) according to the random number table ). The control group was treated with hydrochlorothiazide. The observation group was treated with losartan. Before and after treatment, the blood pressure (SBP), diastolic blood pressure (DBP) and proteinuria (m AIb) and urinary albumin β2 microglobulin (β2-MG)] and adverse reactions. Results There was no significant difference in SBP and DBP between the two groups before treatment (P> 0.05). After treatment, the SBP and DBP in the observation group were lower than those in the control group (P <0.05). The levels of m AIb and β2-MG in the two groups before treatment were not significantly different (P> 0.05), and the levels of m AIb and β2-MG in the observation group were lower than those in the control group after treatment ). No adverse reactions occurred in both groups. Conclusion Losartan treatment of community-based hypertension can effectively control the patient’s blood pressure and improve proteinuria levels.