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目的 :评价平阳霉素碘油乳剂 (PLE)肝动脉栓塞对原发性肝癌肿瘤血管的祛血管作用及其强度和相应临床疗效。方法 :对 11例原发性肝癌肝动脉注入PLE ,同期 18例原发性肝癌以丝裂霉素碘油乳剂 (MLE)作对照 ,观察并比较两组栓塞后肿瘤血管及肿瘤体积变化。结果 :PLE组和MLE组栓塞后肿瘤血管均明显减少 (P <0 .0 1) ,而前者较后者减少更显著 (P <0 .0 1)。栓塞后 1～ 3个月复查两组肿瘤血管均明显缩小 (P <0 .0 5 ) ,但组间变化无明显差异 (P >0 .0 5 )。结论 :PLE对原发性肝癌肿瘤血管有祛血管作用 ,其强度大于MLE。祛血管同时伴随肿瘤体积缩小
Objective: To evaluate the effect of hepatic arterial embolization of Pingyangmycin Lipiodol Emulsion (PLE) on the angiogenesis and its intensity and corresponding clinical efficacy of primary hepatic carcinoma. Methods: PLE was injected into the hepatic artery of 11 cases of primary hepatic carcinoma, and 18 cases of primary hepatocellular carcinoma were treated with mitomycin-lipiodol emulsion (MLE) as controls. The changes of tumor and tumor volume were observed and compared between the two groups. Results: The numbers of tumor vessels in PLE group and MLE group decreased significantly after embolization (P <0.01), while the former decreased more significantly than the latter (P <0.01). One to three months after embolization, the tumor vessels of the two groups were significantly reduced (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: PLE has the effect of removing blood vessels in the tumor of primary liver cancer and its intensity is greater than that of MLE. Dispel the blood vessels along with tumor volume reduction