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据 Nusseblatt 博士报道,环孢霉素 A(Cie-losporin)抑制 Behcet 病症状十分有效。但其作用只是治标的,而文献中描述的副作用如肾功能不良、多毛症、牙龈肥大、乳头瘤形成等等限制本药的广泛应用。另外尚有回跳问题。另一方面,Mizoribine 是一种副作用较小的弱免疫抑制剂,但其作用则较环孢霉素 A 弱得多。对 Behcet 氏的病因和根治、预防的方法仍需进一步探索。局部或全身使用 Mizoribine 有助于在角膜成形术中使角膜植片保持清亮。
According to Dr. Nusseblatt, inhibition of Behcet’s disease by Cie-losporin is very effective. But its role is only a temporary solution, while the side effects described in the literature as renal dysfunction, hirsutism, gingival enlargement, papilloma formation, etc. limit the wide use of the drug. In addition, there are bounce problems. Mizoribine, on the other hand, is a weak immunosuppressive agent with less side effects, but its effect is much weaker than cyclosporine A. Behcet’s etiology and cure, prevention methods still need to be further explored. The use of Mizoribine topically or systemically helps keep the corneal graft clear during keratoplasty.