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本文报告两例结节病伴发隐球菌病患者,一例继发5年,另一例9年之后。作者等进行了免疫学的研究,发现多核白细胞功能、补体结合及血清抗体都属正常范围;而串珠菌素、腮腺炎病毒、链激酶链道酶(SK-SD streptokioase-streptidornase)、结核菌素、组织胞浆菌素、芽生菌素,球孢子菌素以及二硝基氯苯(DNCB)等皮肤迟发过敏反应都为阴性。两例患者用间接荧光检查发现隐球菌抗体及串珠菌、腮腺炎病毒及隐球菌抗原对淋巴细胞反应都有降低。由上述资料,说明两例患者都有细胞中介免疫缺陷。
This article reports two cases of sarcoidosis associated with cryptococcosis, one case secondary to 5 years and the other 9 years later. The authors conducted immunological studies and found that the function of polycaryular leukocytes, complement fixation and serum antibodies are within the normal range; while the antibiotics, mumps virus, streptokinase-streptokinase (SK-SD streptokioase-streptidornase), Mycobacterium tuberculosis Histamine, spiramycin, coccidioidin, and dinitrochlorobenzene (DNCB) were all negative for delayed skin allergy. Two cases of patients with indirect fluorescence test found that cryptococcal antibodies and foci, mumps virus and cryptococcal antigen on lymphocyte responses were reduced. From the above data, indicating that two patients have cell-mediated immune deficiency.