1971年Folkman提出肿瘤细胞生长依赖于新生血管形成的概念,认为肿瘤细胞和血管组成一个高度集合的生态系统,来源于肿瘤细胞或相关炎性细胞的弥散信号能够促使内皮细胞从休止状态变为快速生长状态,提出抗血管形成可能是治疗肿瘤的一个有效手段的假说。近年的研究已经有明确的证据表明,肿瘤生长依赖于血管生成,肿瘤细胞能产生可弥散的血管调节因子,而血管形成拮抗剂能减慢或阻止肿瘤生长。近来一些学者还就肿瘤内微血管密度进行研究,探讨它与肿瘤转移及预后的密切关系。 1.肿瘤新生血管形成与肿瘤的生长、转移肿瘤生长依赖于肿瘤新生血管生成这一概念始于1971年,肿瘤的生长与血管形成密切相关,已经提出来的间接和直 In 1971, Folkman proposed that the growth of tumor cells depends on the concept of neovascularization. He believes that tumor cells and blood vessels form a highly integrated ecosystem. Diffusion signals from tumor cells or related inflammatory cells can prompt endothelial cells to change from resting state to rapid state Growth status, suggesting that anti-angiogenic may be an effective means of treating cancer hypothesis. In recent years, there is clear evidence that tumor growth depends on angiogenesis. Tumor cells can produce diffusible angiogenic factors, whereas angiogenic antagonists can slow down or prevent tumor growth. Recently, some scholars also study the microvessel density in the tumor to explore its close relationship with tumor metastasis and prognosis. 1. Tumor neovascularization and tumor growth, metastasis Tumor growth depends on the concept of neovascularization began in 1971, the tumor growth and vascular formation are closely related to the indirect and direct have been proposed