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目的:探析小细胞肺癌放疗前后CEA(癌胚抗原)、NSE(糖分解烯醇酶)、CYFRA21-1(细胞角蛋白19片段抗原)检测的临床意义。方法:选择我院2016年5月-2017年5月所收治的30例小细胞肺癌患者为本次研究的观察组,另选同期来我院体检的30例健康人员作为本次研究的对照组。收集观察组放疗前后体内CEA、NSE、CYFRA21-1检测结果,并将其与对照组检测结果进行对比。结果:由本次研究可知,观察组患者在放疗前,其CEA、NSE、CYFRA21-1水平远高于对照组,其差异具有统计学意义(P<0.05)。在放疗后有明显下降(P<0.05),且与对照组无显著差异(P>0.05)。结论:小细胞肺癌患者CEA、NSE、CYFRA21-1水平显著高于常人,其临床检测有助于提高小细胞肺癌的确诊率。
Objective: To investigate the clinical significance of CEA (Carcinoembryonic Antigen), NSE (Carbohydrate Enolase), CYFRA21-1 (cytokeratin 19 fragment antigen) in small cell lung cancer before and after radiotherapy. Methods: Thirty patients with small-cell lung cancer who were admitted to our hospital from May 2016 to May 2017 were selected as the observation group and another 30 healthy people from our hospital during the same period were selected as the control group . The CEA, NSE and CYFRA21-1 results of the observation group before and after radiotherapy were collected and compared with those of the control group. Results: From this study, before the treatment, the levels of CEA, NSE and CYFRA21-1 in the observation group were significantly higher than those in the control group (P <0.05). There was a significant decrease after radiotherapy (P <0.05), and no significant difference with the control group (P> 0.05). Conclusion: The levels of CEA, NSE and CYFRA21-1 in patients with small cell lung cancer are significantly higher than those in normal people. The clinical examination of CEA, NSE and CYFRA21-1 may help to improve the diagnosis of small cell lung cancer.