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目的以氨甲蝶呤(MTX)为对照,探讨米非司酮配伍中药在异位妊娠保守治疗中的作用。方法将50例患者随机分为米非司酮配伍中药组和氨甲蝶呤组进行比较。以氨甲蝶呤(MTX)为对照,观察米非司酮配伍中药治疗异位妊娠的效果。结果2组均于治疗后10d血人绒毛膜促性腺激素(β-hCG)开始明显下降,治疗后15d包块平均直径明显缩小,与治疗前比较差异有统计学意义(P<0.05)。米非司酮配伍中药和氨甲蝶呤治疗成功率分别为92%和76%。两者比较差异有统计学意义。结论米非司酮配伍中药治疗异位妊娠的效果优于氨甲蝶呤,且MTX有一定的不良反应,而米非司酮配伍中药无一例发生不良反应,给药方便,作为异位妊娠保守治疗的药物,有一定的临床意义和应用前景。
Objective To compare the effect of mifepristone and traditional Chinese medicine in the conservative treatment of ectopic pregnancy with methotrexate (MTX) as a control. Methods 50 patients were randomly divided into mifepristone with traditional Chinese medicine group and methotrexate group for comparison. Methotrexate (MTX) as a control, observe the efficacy of mifepristone with traditional Chinese medicine treatment of ectopic pregnancy. Results The levels of β-hCG in the two groups were significantly decreased 10 days after treatment. The mean diameter of the lumps was significantly reduced 15 days after treatment, with statistical significance (P <0.05). Mifepristone compatibility of traditional Chinese medicine and methotrexate treatment success rates were 92% and 76%. The difference between the two was statistically significant. Conclusion The effect of mifepristone combined with traditional Chinese medicine in the treatment of ectopic pregnancy is superior to that of methotrexate, and MTX has some adverse reactions. However, none of mifepristone and traditional Chinese medicines has adverse reactions, which is convenient for administration and conservative as ectopic pregnancy Treatment of drugs, there are some clinical significance and application prospects.