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测定 31例老年原发性高血压 ,2 3例老年原发性高血压伴腔隙性脑梗塞及 2 3例健康老年人血中血栓素 B2(TXB2 ) ,血 6 -酮前列腺素 F1 a (6 - k- PGF1 a)的浓度。结果老年原发性高血压及伴腔隙性脑梗塞组血 TXB2 与健康对照组比较显著增高 ,而 6 - K- PGF1 a无显著差异 ;老年原发性高血压无腔隙性脑梗塞组血 TXB2 较伴腔隙性脑梗塞组为低 ,但无显著差异。说明高血压病无论是否合并腔隙性脑梗塞 ,均存在血小板激活的表现 ,而伴腔隙性脑梗塞组更突出 ,提示早期预防具有重要意义。
Twenty - one elderly patients with essential hypertension, 23 elderly patients with essential hypertension accompanied by lacunar infarction and 23 healthy controls were measured for TXB2, 6α - keto - prostaglandin F1α 6-k-PGF1 a). Results The levels of TXB2 in senile essential hypertension and lacunar infarction group were significantly higher than those in healthy control group, while there was no significant difference in 6 - K - PGF1 a group. The senile hypertension without lacunar infarct group TXB2 with lacunar infarction group was lower, but no significant difference. Whether hypertension complicated with lacunar infarction, there is the performance of platelet activation, and more prominent with lacunar infarction group, suggesting that early prevention is of great significance.