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辅助生殖技术的应用带来最突出的问题之一就是多胎妊娠率增高(较正常妊娠高10倍),导致相应妊娠并发症增多,严重危及母子健康和安全。选择性减胎术的应用虽然降低妊娠并发症的发生,但减胎术导致的并发症不容忽视。自然减胎(SPR)是指妊娠过程中胚胎数目自然减少,有研究证实,自然减胎多发生在妊娠早期,其发生原因可能与胚胎数量、妊娠年龄及胚胎质量有关,并且常并发妊娠期缩短,新生儿出生体质量降低及阴道流血等。对自然减胎发生机制、发生时间及其对妊娠结局的影响作较全面综述。
One of the most prominent problems brought by the application of assisted reproductive technology is the increase of multiple pregnancy rate (10 times higher than that of normal pregnancy), resulting in the increase of corresponding pregnancy complications, which seriously endangers the health and safety of mother and child. Although the application of selective abortion reduces the incidence of pregnancy complications, the complications caused by abortion can not be ignored. Natural abortion (SPR) refers to the natural reduction in the number of embryos during pregnancy, studies have confirmed that natural abortion mostly occurs in early pregnancy, its causes may be related to the number of embryos, gestational age and embryo quality, and often complicated by pregnancy shortened , Neonatal birth weight reduction and vaginal bleeding. The mechanism of spontaneous abortion, its timing and impact on pregnancy outcomes are reviewed in more detail.