论文部分内容阅读
目的 :了解复发性口疮 (RAU)的疗效高低对血清NO ,NOS水平的影响 ,探讨血清NO ,NOS水平的变化在RAU发病中的作用 ,为其防治提供理论根据。方法 :对 2 4 3例RAU患者治疗前 ,治疗后近期及远期有效与无效者血清NO ,NOS的水平进行比较。结果 :①RAU治疗前血清NO ,NOS水平高于健康对照者 (NO :t =1 6 0 53 ,P <0 0 0 1 ;NOS:t =1 0 1 2 3 ,P <0 0 0 1 )。②近期随访 ,血清NO ,NOS水平 ,有效者低于无效者 (NO :t =1 3 62 0 ,P <0 0 0 1 ;NOS:t=6 .80 0 ,P <0 0 0 1 )。有效者低于治疗前 (NO :t=1 9.42 ,P<0 0 0 1 ;NOS :t=1 3 730 ,P<0 0 0 1 ) ;血清NO水平有效者高于健康对照者 (t=6 941 ,P <0 0 0 1 ) ,血清NOS水平有效者与健康对照者无差异 (t=1 2 0 3 ,P <0 0 5)。③远期随访 ,血清NO ,NOS水平 ,有效者低于无效者 (NO :t =1 7 1 30 ,P <0 0 0 1 ;NOS :t=3 2 50 ,P <0 0 0 1 )。有效者低于治疗前 (NO :t =2 3 980 ,P <0 0 0 1 ;NOS :t =1 8 51 0 ,P <0 0 0 1 )。有效者高于健康对照者(NO :t =4.2 57,P <0 0 0 1 ;NOS :t =4.359,P <0 0 0 1 )。结论 :RUA体内NO ,NOS增多参与致病 ,减少有利病情好转。这对RAU的监测与防治具有重要意义
Objective: To investigate the effect of recurrent aphthous ulcer (RAU) on serum NO and NOS levels and explore the role of serum NO and NOS levels in the pathogenesis of RAU to provide theoretical basis for its prevention and treatment. Methods: The levels of NO and NOS in 243 patients with RAU before and after treatment were compared between the short-term and long-term effective and ineffective. Results: ① The serum levels of NO and NOS in RAU before treatment were higher than those in healthy controls (NO: t = 1 6 053, P 0 01; NOS: t 1 01 2 3, P 0 01). (2) In the recent follow-up, serum NO and NOS levels were lower than those in inactive patients (NO: t = 136200, P <0.01; NOS: t = 6.800, P <0.01). The effective rate was lower than before treatment (NO: t = 1 9.42, P <0.01; NOS: t = 13 730, P <0.01) 6 941, P 0 01). No significant difference was found between serum NOS level and healthy controls (t = 1203, P <0 05). ③ Long-term follow-up, serum NO and NOS levels were lower than those with no effect (NO: t = 1 7 1 30, P 0 01; NOS t = 3 2 50, P 0 01). The effective rate was lower than before treatment (NO: t = 23 980, P <0.01; NOS: t = 185100, P <0.01). The effective rate was higher than the healthy control (NO: t = 4.257, P <0.01; NOS: t = 4.359, P <0.01). Conclusion: The increase of NO and NOS in RUA is involved in the pathogenesis and reduces the favorable condition. This is of great significance to the monitoring and prevention of RAUs