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目的:评估茵陈蒿汤和熊去氧胆酸两药合用与单用熊去氧胆酸治疗妊娠期肝内胆汁淤积症(ICP)及改善围生儿预后的疗效。方法:将60例ICP住院患者随机分为两组。A组采用茵陈蒿汤与熊去氧胆酸合用治疗,B组单用熊去氧胆酸治疗。治疗3周后观察瘙痒症状,血清生化指标(甘胆酸、胆红素、转氨酶),分娩后比较两组围生儿预后情况。结果:两组治疗后瘙痒症状、血清甘胆酸、胆红素、转氨酶A组较B组疗效明显改善(P<0.05),但治疗后两组间围生儿预后差异无显著性(P>0.05)。结论:茵陈蒿汤与熊去氧胆酸合用比单用熊去氧胆酸治疗ICP疗效更显著,而价廉、安全,患者易接受,适宜推广。
Objective: To evaluate the curative effect of combination of Yinchenhao Decoction and ursodeoxycholic acid with ursodeoxycholic acid alone in the treatment of intrahepatic cholestasis of pregnancy (ICP) and to improve prognosis of perinatal children. Methods: Sixty patients with ICP were randomly divided into two groups. Group A was treated with Yinchenhao Decoction and Ursodeoxycholic acid, and Group B with Ursodeoxycholic acid alone. Pruritus symptoms and serum biochemical indexes (glycocholic acid, bilirubin and aminotransferase) were observed after 3 weeks of treatment. The prognosis of perinatal children after delivery was compared. Results: The curative effect of pruritus symptom, serum glycocholic acid, bilirubin and aminotransferase A group were significantly improved (P <0.05), but there was no significant difference in the prognosis between the two groups after treatment (P> 0.05). Conclusion: The combination of Yinchenhao Decoction and Ursodeoxycholic acid is more effective than Ursodeoxycholic acid alone in the treatment of ICP, but it is cheap, safe and easy to be accepted by patients.