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已有报道用免疫抑制剂如大剂量6-甲基强的松龙(HDMP)、抗淋巴细胞球蛋白(ALG)和抗胸腺细胞球蛋白(ATG)成功治疗部分重型再障(SAA)。本文报告2例用ATG和小剂量皮质激素治疗无效的SAA患者用ATG和HDMP联合治疗获成功。例1,15岁男孩,确诊为SAA。先用ATG 15mg/kg/日和MP 40mg/日,分别静脉滴注10天,另外口服MP4-12mg、每6小时1次(主要目的是防止血清病),治疗35天后血象和骨髓象无改善。治疗第45天进行第二疗程ATG 15mg/kg/日×10天,同时每日分次给予HDMP 500mg/日,治疗过程中患者粒细胞开始上升,骨髓活检出现了造血岛,血象也上升,至诊断后11个月血象完全恢复正常。例2,19岁,黑人男性,确诊为SAA。开始用
It has been reported that successful treatment of partial severe aplastic anemia (SAA) with immunosuppressive agents such as high-dose 6-methylprednisolone (HDMP), anti-lymphocyte globulin (ALG) and antithymocyte globulin (ATG) This article reports 2 cases of ATA and low-dose corticosteroids ineffective SAA patients with ATG and HDMP combined treatment was successful. Example 1, 15 year old boy, diagnosed as SAA. First with ATG 15mg / kg / day and MP 40mg / day, respectively, intravenous infusion of 10 days, another oral MP4-12mg, every 6 hours 1 (the main purpose is to prevent serum disease), after 35 days of treatment of blood and bone marrow showed no improvement . On the 45th day of treatment, the second course of ATG 15mg / kg / day × 10 days, while daily HDMP 500mg / day, during treatment, patients began to increase in granulocytes, bone marrow biopsy hematopoietic island appeared, the blood also increased, to Eleven months after the diagnosis of blood returned to normal. Example 2, 19 years old, black man, diagnosed as SAA. Start to use