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Objective To compare the clinical effectiveness of different scheme of pharmacotherapy in treatment of combined cardiac pathology.Methods The was completed comparative analysis of different regimens using various ACE inhibitors (perindopril and fosinopril) in patients with combined cardiovascular pathology.Results The results of treatment showed improvement in hemodynamic and clinical parameters.Conclusion The results of the study point to the pronounced clinical efficacy of combined therapy in both groups of patients with concomitant cardiac pathology.