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已知肾素-血管紧张素-醛固酮系统在高血压发病中起重要作用。其中的血管紧张素Ⅱ(Ang Ⅱ)活性过强,是导致体液调节失衡、高血压及终末器官结构和功能异常的重要病理生理学基础。血管紧张素Ⅱ受体拮抗剂可阻断Ang Ⅱ与Ang Ⅱ受体的结合,从而使Ang Ⅱ不能产生其生物学效应。实验证明,Ang Ⅱ受体有两种亚型AT1和AT2受体(An-
The renin-angiotensin-aldosterone system is known to play an important role in the pathogenesis of hypertension. Angiotensin II (Angiotensin II) is an important pathophysiological basis that leads to imbalance of body fluid regulation, hypertension and structural and functional abnormalities of terminal organs. Angiotensin Ⅱ receptor antagonists can block the binding of Ang Ⅱ to Ang Ⅱ receptor, so Ang Ⅱ can not produce its biological effects. Experiments show that, Ang Ⅱ receptor has two subtypes of AT1 and AT2 receptors (An-