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Zinc chloride is an efficient and safe catalyst in the[3 + 2]cycloaddition reaction of organic nitriles with sodium azide in solventless condition.The corresponding S-substituted 1H tetrazoles were obtained under mild conditions.This method can overcome disadvantages such as:the use of toxic metals and expensive reagents,drastic reaction conditions,water sensitivity and the presence of dangerous hydrazoic acid.
Zinc chloride is an efficient and safe catalyst in the [3 + 2] cycloaddition reaction of organic nitriles with sodium azide in solventless condition. The corresponding S-substituted 1H tetrazoles were obtained under mild conditions. This method can be overcome: of toxic metals and expensive reagents, drastic reaction conditions, water sensitivity and the presence of dangerous hydrazoic acid.