目的检测Nusap1基因蛋白在肝癌手术切缘中的表达情况及其与肿瘤早期复发的关系。方法选择常规病理学检查手术切缘为阴性的原发性肝癌标本61例,用免疫组化法检测手术切缘Nusap1基因蛋白表达情况。结果肝癌手术切缘中Nusap1蛋白表达阳性有21例,其中15例术后早期复发(71.4%);阴性40例,术后仅12例出现早期复发(30%);阳性组术后早期复发率明显高于阴性组,差异有显著性(P<0.05)。结论肝癌手术切缘中Nusap1蛋白表达与术后早期复发明显相关,可预测肝癌术后早期复发高危患者及指导术后辅助治疗。 Objective To detect the expression of Nusap1 protein in the surgical margin of hepatocellular carcinoma (HCC) and its relationship with early tumor recurrence. Methods Totally 61 cases of primary hepatocellular carcinoma (HCC) were examined by routine pathology. The protein expression of Nusap1 was detected by immunohistochemistry. Results Totally 21 cases were positive for Nusap1 protein in surgical resection of liver cancer, of which 15 cases were early recurrence (71.4%), 40 cases were negative, and only 12 cases showed early recurrence (30%) after operation. The early postoperative recurrence rate Significantly higher than the negative group, the difference was significant (P <0.05). Conclusion The expression of Nusap1 in the surgical margin of hepatocellular carcinoma is significantly correlated with the early postoperative recurrence, which can predict the early postoperative recurrence of liver cancer patients and guide postoperative adjuvant therapy.