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目的 :应用躯体感觉诱发电位 (SEP)的脑功能评价法观察纳洛酮对脑梗死即刻效应。方法 :68例急性大脑中动脉区梗死病人 ,分为内囊组 (n =17)、放射冠组 (n =2 9)和皮质组 (n =2 2 ) ,给予纳洛酮 0 .8mg ,im ,st,分析纳洛酮治疗前后的SEP表现 ,观察指标为N2 0 波幅。结果 :纳洛酮治疗前后N2 0 波幅 ,在内囊组分别为 76± 19和 112± 33,P <0 .0 1,在放射冠组分别为 70± 2 0和 4 9± 17,P <0 .0 1,在皮质组分别为 5 3± 2 1和 74± 2 4 ,P <0 .0 1;各组临床表现、梗死灶大小与治疗前N2 0 波幅相关。结论 :纳洛酮短时间内提高了内囊梗死和皮质梗死的大脑皮层兴奋性 ,降低了放射冠梗死的大脑皮层兴奋性。
OBJECTIVE: To evaluate the immediate effect of naloxone on cerebral infarction by evaluating the brain function of somatosensory evoked potential (SEP). Methods: Sixty-eight patients with acute middle cerebral artery infarction were divided into internal capsule group (n = 17), radiation crown group (n = 29) and cortex group (n = 22) im, st, analysis of naloxone before and after treatment of SEP performance, the observed index of N2 0 amplitude. Results: The amplitude of N2 0 before and after naloxone treatment were 76 ± 19 and 112 ± 33 in the balloon group, P <0.01, and 70 ± 20 and 49 ± 17 in the radiotherapy group, P < 0 .0 1 in the cortical group were 53 ± 2 1 and 74 ± 2 4, P <0. 01; the clinical manifestations of each group, infarct size and N2 0 amplitude before treatment. CONCLUSIONS: Naloxone increases the excitability of the cerebral cortex of internal infarcts and cortical infarcts in a short period of time and decreases the excitability of cerebral cortex in patients with coronary artery infarction.