【摘 要】
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Bioactivity-guided fractionation led to the isolation of a new steroidal saponin,orbiculatoside B, together with a pair of furostanol saponins, protobioside and
【机 构】
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Department of Natural Products Chemistry,Beijing Institute of Biomedicine,Kunming institute of Botan
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Bioactivity-guided fractionation led to the isolation of a new steroidal saponin,orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside,from the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata. The new compound was identified to be isonarthogenin 3 - O - α - L - rhamnopyranosyl (1→2) - [ α - L - rhamnopyranosyl- ( 1→ 4 ) ] - β - D - glucopyranoside by various NMR techniques in combination with chemical methods. The three saponins showed strong activity against Pyricularia oryzae, and were cytotoxic to cancer cell line K562, HCT-15, A549, and A2780a in vitro.
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