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目的 观察去甲长春花碱联合顺铂治疗晚期非小细胞肺癌的近期疗效和安全性。方法 应用去甲长春花碱 (2 5～ 30mg/m2 ,d1、d8)加顺铂 (5 0mg,d2、d3)治疗非小细胞肺癌 2 2例。结果 取得完全缓解 1例 ,部分缓解9例 ,总有效率 45 .46 % ;初治者有效率 6 2 .5 0 % ,复治者 2 8.5 7% ;腺癌有效率 6 1.5 4% ,鳞癌 2 2 .2 2 %。主要毒副反应为白细胞减少 ,发生率 95 .45 % ,其中Ⅲ～Ⅳ度占 40 .91% ;常规止吐治疗后 ,消化道反应较轻 ,静脉炎发生率 13.6 4% (仅 3例 )。结论 去甲长春花碱联合顺铂是目前治疗晚期非小细胞肺癌最有效的方案之一 ,毒副反应可耐受
Objective To observe the short-term efficacy and safety of norepinephrine and cisplatin in the treatment of advanced non-small cell lung cancer. Methods Navelbine (2 5-30 mg/m2, d1, d8) plus cisplatin (50 mg, d2, d3) were used to treat 22 patients with NSCLC. The results achieved complete remission in 1 case, partial remission in 9 cases, total effective rate of 45.46%; initial treatment effective rate of 22.50%, retreatment of 28.57%; adenocarcinoma effective rate of 61.54%, scales Cancer 2 2 .2 2%. The main toxicity was leukopenia, with an incidence of 95.45%, of which III-IV degree accounted for 40.91%; after antiemetic treatment, the digestive tract reaction was lighter and the incidence of phlebitis was 13.6% (only 3 cases). . Conclusion Navelbine combined with cisplatin is one of the most effective regimens for the treatment of advanced non-small cell lung cancer. Toxicity can be tolerated